Dillian Whyte has vowed to prove his innocence after returning “adverse analytical findings” in a doping test that led to the cancellation of his bout against Anthony Joshua next Saturday.

An eagerly-anticipated rematch between the British heavyweights was called off by Matchroom after the Voluntary Anti-Doping Association informed the promoters and boxing authorities about the test result.

It is understood Joshua could still fight at London’s O2 Arena as Matchroom seek a late replacement opponent for the former two-time world heavyweight champion but Whyte faces a battle to clear his name.

He wrote on his social media channels: “I am shocked and devastated to learn of a report by VADA of adverse findings relating to me.

“I only learned of it this morning and am still reacting to it. I have also just seen that the fight is being cancelled without having any chance to demonstrate my innocence before the decision was taken.

“I can confirm without a shadow of doubt that I have not taken the reported substance, in this camp or at any point in my life.

“I am completely innocent and ask to be given the time to go through the process of proving this without anybody jumping to conclusions or a trial by media.”

Whyte served a two-year drugs ban from 2012 to 2014 and was cleared of a doping violation in 2019 after UK Anti-Doping concluded the levels in his sample were “very low” and he was ultimately not to blame.

The Londoner added: “I insisted on 24/7 VADA testing for this fight, as I have done voluntarily and at my own expense for all of my fights for many, many years.

“This is not the first time that I have been reported as having an adverse finding for a substance which I have not taken, and as I did last time I will again prove that I am completely innocent.

“In the meantime all I can do is express my extreme disappointment to boxing fans, who will miss out on what was sure to be a great event.”

Whyte suffered his first professional defeat in December 2015 after being stopped by Joshua, who avenged a loss to his British rival in their amateur days.

While Joshua went on to win a world title in his next bout, Whyte rebuilt with 11 straight victories to become the WBC’s mandatory challenger before a savage knockout defeat to Alexander Povetkin in 2020.

He gained revenge in the immediate rematch but his only world title tilt to date ended in disappointing fashion when he was stopped by WBC heavyweight champion Tyson Fury in the sixth round in April 2022.

He rebounded with an unconvincing majority points win over Jermaine Franklin last November in his most recent bout, while Joshua received criticism for his performance against the American in April.

That set the British pair on a collision course once again, and another win over Whyte would have put Joshua on the road to a showdown against ex-WBC champion Deontay Wilder in December in Saudi Arabia.

However, Matchroom said in a statement on Saturday morning: “Today, the Voluntary Anti-Doping Association (VADA) informed Matchroom, the Association of Boxing Commissions and the British Boxing Board of Control that Dillian Whyte had returned adverse analytical findings as part of a random anti-doping protocol.

“In light of this news, the fight will be cancelled and a full investigation will be conducted.”